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Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 31-52 doi: 10.1007/s11684-013-0251-9

Abstract: Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabeticThe associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem fromHowever, whether there is a clear cause-and-effect relationship of Zn with metabolic syndrome, diabetesTheoretically Zn supplementation should prevent the metabolic syndrome, diabetes, and diabetic complicationssyndrome, diabetes, and diabetic complications.

Keywords： zinc     zinc transporters     metallothionein     diabetes     diabetic complications     insulin resistance     antioxidant    

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Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia

Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 130-138 doi: 10.1007/s11684-017-0555-2

Abstract: providing new promising strategies for future clinical application of BAT activation to treat obesity and metabolicThis review focuses on recent advances of BAT function in the metabolic aspect and the relationship between

Keywords： brown adipose tissue     beige adipocyte     anti-obesity     anti-diabetes     cancer cachexia     aging    

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Association between history of abortion and metabolic syndrome in middle-aged and elderly Chinese women

Baihui Xu, Jie Zhang, Yu Xu, Jieli Lu, Min Xu, Yuhong Chen, Yufang Bi, Guang Ning

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 132-137 doi: 10.1007/s11684-013-0250-x

Abstract: Until recently, studies focusing on the association between history of abortion and metabolic diseasesIn the present study, we aimed to investigate the association between history of abortion and metabolicsyndrome (MetS) in middle-aged and elderly Chinese women.

Keywords： induced abortion     spontaneous abortion     metabolic syndrome    

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Association of metabolic syndrome with arterial compliance in children and adolescents

ZHANG Li, MI Jie, LI Ming, JIANG Benyu

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 68-73 doi: 10.1007/s11684-007-0014-6

Abstract: The association of metabolic syndrome (MS) with arterial compliance in children and adolescents was explored3.01) years, out of Beijing Child Metabolic Syndrome Study , were divided into three case groups (one

Keywords： compliance assessment     correlation analysis     cardiovascular     clustering     HOMA-IR    

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High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 651-663 doi: 10.1007/s11684-019-0709-5

Abstract: This study used the established Yang Huang syndrome (YHS) mouse model to evaluate the efficacy of geniposideUrine metabolic data were quantified by ultra-performance liquid chromatography–tandem mass spectrometryMeanwhile, heme oxygenase-1, a prediction of network pharmacology, was the confirmed metabolic enzymeis a robust combination for deciphering the pathogenesis of the traditional Chinese medicine (TCM) syndrome

Keywords： metabolomics     liquid chromatography-mass spectrometry     metabolites     metabolic pathways    

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Polycystic ovary syndrome

Zi-Jiang CHEN, Yuhua SHI

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 280-284 doi: 10.1007/s11684-010-0098-2

Abstract: Polycystic ovary syndrome (PCOS) is a common gynecologic endocrinopathy.PCOS has additional metabolic derangements, such as insulin resistance, impaired glucose tolerance, andThe risks of diabetes, cardiovascular disease, hypertension, metabolic syndrome, and endometrial cancer

Keywords： polycystic ovary syndrome     genetics     metabolic disturbance    

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Joint association of physical activity/screen time and diet on CVD risk factors in 10-year-old children

Clemens Drenowatz, Joseph J. Carlson, Karin A. Pfeiffer, Joey C. Eisenmann

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 428-435 doi: 10.1007/s11684-012-0232-4

Abstract:

The increasing prevalence of childhood overweight and obesity has been associated with an increased risk for cardiovascular disease (CVD). While several studies examined the effect of single behaviors such as physical activity (PA), sedentary behavior or diet on CVD risk, there is a lack of research on combined associations, specifically in children. Therefore, the purpose of this study was to examine the joint association of PA or screen time (ST) and diet on CVD risk factors in children. PA, ST and diet were assessed via questionnaire in 210 fifth grade students (age: 10.6±0.4 years). The healthy eating index (HEI) was subsequently calculated as indicator for diet quality. Height, weight, % body fat, and resting blood pressure were measured according to standard procedures and blood samples obtained via fingerprick were assayed for blood lipids. Total cholesterol HDL ratio (TC:HDL), mean arterial pressure (MAP), and % body fat were used as indicators of CVD risk. 55% of children did not meet current PA recommendations on at least 5 days/week and 70% exceeded current recommendations for ST. Further, only 2.5% possessed a “good” diet (HEI>80). There was no significant association of PA or ST and diet on CVD risk score. Neither TC:HDL, MAP, and % body fat nor the total CVD risk score was significantly correlated with diet, PA, or ST. Children in the high PA group, however, had significantly better diet scores. Despite the fact that self-reported PA, ST, or dietary intake were not directly related to CVD risk in this sample, higher activity levels were associated with a healthier diet and lower ST indicating an overall healthier lifestyle of this subgroup.

Keywords： exercise     sedentary behavior     metabolic syndrome     health behavior     adolescents     TV time     healthy eating index    

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New insights into different surfactants’ impacts on sludge fermentation: Focusing on the particular metabolic

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1527-6

Abstract:

• The promoting effects for VFA generation follow the order of APG>SDBS>HTAB.

Keywords： Waste activated sludge (WAS)     Volatile fatty acids (VFA)     Surfactant types     Functional microorganisms     Metabolic    

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Metabolic hypertension: concept and practice

Zhiming Zhu, Peijian Wang, Shuangtao Ma

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 201-206 doi: 10.1007/s11684-013-0264-4

Abstract: More than 60% of the risk factors for hypertension are associated with metabolic disturbances.Metabolic abnormalities increase the risk for hypertension and cause high blood pressure.Improving metabolic disturbances is beneficial for hypertension treatment.Due to the importance of metabolic abnormalities in the pathogenesis of hypertension, we propose a conceptof metabolic hypertension.

Keywords： hypertension     cardiometabolic risk factors     metabolic abnormalities    

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract:

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 651-658 doi: 10.1007/s11684-021-0859-0

Abstract: To present the clinical characteristics and the misdiagnosis rate of acute coronary syndrome manifestedcomplaint of throat discomfort, absence of chest pain at onset, and an ultimate diagnosis of acute coronary syndromedyspnea, perspiring, and exertional throat symptoms were significantly associated with acute coronary syndromeThroat discomfort can be the principal manifestation of acute coronary syndrome.throat symptoms, chest tightness, perspiring, and dyspnea were important indicators of acute coronary syndrome

Keywords： acute coronary syndrome (ACS)     throat discomfort (TD)     throat pain     cardiology departments     non-cardiologic    

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electron transfer and its application in dictating routes of biochemical processes associated with metabolic

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 679-692 doi: 10.1007/s11684-021-0866-1

Abstract: Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increasedelectron transfer (PET), which is used to characterize the degree of electron redistribution coupled with metabolicEnabling electron transfer could drive metabolic reprogramming in cancer metabolism.

Keywords： metabolic reprogramming     potential of electron transfer     cell proliferation     aerobic glycolysis     cancer    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract: relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolicpharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

Maryanne Caruana,Mary N. Sheppard,Wei Li

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 419-426 doi: 10.1007/s11684-014-0383-6

Abstract: of Valsalva has been most extensively documented in the setting of aortopathies, particularly Marfan syndromereview, we carried out a literature search on aneurysmal dilatation of the sinuses of Valsalva in Marfan syndromeIn conclusion, there are differences in management of aortic dilatation in Marfan syndrome and congenital

Keywords： sinus of Valsalva aneurysms     Marfan syndrome     aortic dissection    

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Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 173-186 doi: 10.1007/s11684-015-0384-0

Abstract:

Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.

Keywords： metformin     diabetes     hepatic steatosis     inflammatory response     insulin resistance    

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Title Author Date Type Operation

Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Journal Article

Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia

Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee

Journal Article

Association between history of abortion and metabolic syndrome in middle-aged and elderly Chinese women

Baihui Xu, Jie Zhang, Yu Xu, Jieli Lu, Min Xu, Yuhong Chen, Yufang Bi, Guang Ning

Journal Article

Association of metabolic syndrome with arterial compliance in children and adolescents

ZHANG Li, MI Jie, LI Ming, JIANG Benyu

Journal Article

High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Journal Article

Polycystic ovary syndrome

Zi-Jiang CHEN, Yuhua SHI

Journal Article

Joint association of physical activity/screen time and diet on CVD risk factors in 10-year-old children

Clemens Drenowatz, Joseph J. Carlson, Karin A. Pfeiffer, Joey C. Eisenmann

Journal Article

New insights into different surfactants’ impacts on sludge fermentation: Focusing on the particular metabolic

Journal Article

Metabolic hypertension: concept and practice

Zhiming Zhu, Peijian Wang, Shuangtao Ma

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Journal Article

electron transfer and its application in dictating routes of biochemical processes associated with metabolic

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

Maryanne Caruana,Mary N. Sheppard,Wei Li

Journal Article

Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Journal Article